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Mice were labelled with Calcr-Cre crossed to a tdTomato Cre-reporter line and stained for Glp1r expression to quantify co-expression

We also demonstrate metformin-mediated alterations to cell cycle distribution and progression following radiation in HCT116 and SW837 cells, with metformin demonstrated to reduce the proportion of G2/M phase cells and prevent radiation-induced G2/M blockade in these cells