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Rare de novo missense variants in RNA helicase DDX6 cause intellectual disability and dysmorphic features and lead to P-body defects and RNA dysregulation

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Papules appear over the next three to four days, and develop into vesicles within one to two days (Figure 2).7 The vesicles then begin to pustulate within one week, followed by ulceration (which may appear black) and crusting three to five days later

In patients with chronic metabolic strain, elevated inflammatory markers, or neurologic concerns, the demand placed on redox balance often becomes an important part of the clinical picture