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Abbreviations AOAA aminooxyacetic acid AVG L-aminoethoxyvinylglycine BCA -cyano-L-alanine CARS cysteinyl-tRNA synthetase CBS cystathionine -synthase CSE cystathionine -lyase HMPSNE 2-[(4-hydroxy-6-methylpyrimidin-2-yl)sulfanyl]-1-(naphthalen-1-yl)ethan-1-one MST 3-mercaptopyruvate sulfurtransferase NAC N-acetylocysteine PAG DL-propargyl-glycine PLP pyridoxal phosphate RSS reactive sulfur species Competing Interests These authors declare that there are no competing interests associated with the manuscript

IGF-1 LR3 retains the ability to bind IGF-1 and insulin receptors but has reduced binding affinity to insulin-like growth factor-binding proteins (IGFBPs)

Epigenetic alterations, including decreased DNA methylation and modified histone marks (H3K9, H4K12), further compromise oocyte quality and meiotic progression [99]

Epitalons antioxidant and anti-mutagenic actions arent species-limited