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It has an important function in the maintenance of RBC homeostasis via the interaction with signal regulatory protein alpha (SIRP) [278]

This maintains peptide potency while preventing the needle channel from acting as a contamination pathway

[3] At the 12 mg dose, the mean weight reduction was about 17.5% at 24 weeks (the primary endpoint) rising to roughly 24.2% at 48 weeks , compared with about 2.1% for placebo