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This mechanism is supported by Pickarts foundational research on GHK-Cu and tissue remodeling, which established the peptides role in accelerating wound closure and improving the structural quality of regenerated tissue

The authors also point out that in some rare genetic disorders of B12 metabolism, the active forms may be required, and that smokers, who tend to have an excess of thiocyanate in their blood, may benefit from a taking a form other than cyano-B12

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