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Based on the above research findings, we hypothesize that beneficial Clostridium and its metabolites regulate adaptive immunity and induce immune tolerance in RA, thereby synergistically alleviating joint immune damage

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Glutathione biosynthesis occurs in two sequential, ATP-dependent enzymatic steps that take place in the cytosol: Step 1: The enzyme glutamate-cysteine ligase (GCL) combines glutamate and cysteine to form gamma-glutamylcysteine

When at least one follicle 14 mm of diameter was observed, pituitary suppression was initiated with a GnRH antagonist (0.25 mg of cetrorelix acetate, Cetrotide