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The metabolism of arginine, tryptophan and glutamate is closely linked within the cell through shared intermediary metabolites, signaling pathways and regulatory networks, and these three amino acids are synergistically involved in core life activities such as cellular energy metabolism, redox homeostasis, signaling, and immunomodulation ( Figure 3 )

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Combining it with benzodiazepines, Z-drugs, or alcohol creates additive CNS depressant effects

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