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69 Wound healing has been an active area of research, and the use of GLP-1RAs has been shown to improve wound healing by increasing keratinocyte migration, PI3K/Akt activation, increasing fibroblasts, myofibroblasts, and vessel density, activation of AMPK, and decreasing CRP and MMP-9/TIMP-1 ratio

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[DOI] [PubMed] [Google Scholar] 136.Gamulin O., Oroz K., Coric L., Krajacic M., Skrabic M., Dretar V., Strbe S., Talapko J., Juzbasic M., Krezic I., et al

Weight loss at the 48-week mark had not yet plateaued in most dose groups, suggesting that longer treatment periods could produce even greater results