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0.25 g/L) or saline (bilaterally, for 2 min at a rate of 0.05 L/min)

Their half-lives are 13 hours (LIRA) and 7 days (SEMA), allowing for daily and weekly subcutaneous administration, respectively, thanks to the structural modifications introduced.5,10 Effects on obesity and glycaemic control Both LIRA 3 mg and SEMA 2.4 mg have demonstrated a strong appetite-suppressing and satiety-promoting effect, as well as a delaying effect on gastric emptying.11,12 The SCALE programme highlighted the efficacy of LIRA 3 mg in reducing body weight and waist circumference13 and confirmed a reduction in HbA1c levels in individuals with diabetes, along with a decreased progression from prediabetes to diabetes after three years of treatment14 (Table 1)

(2006) Modern nutrition in health and disease

Key Questions Answered: Q: Why do two people taking the exact same dose of a GLP-1 drug experience completely different weight-loss results