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This cardiovascular outcomes trial of semaglutide versus placebo in patients with type 2 diabetes at high cardiovascular risk revealed an unexpected finding: patients receiving semaglutide experienced a statistically significant increase in diabetic retinopathy complications (hazard ratio 1.76, 95% CI 1.112.78, p=0.02)

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The first incubation lasted 1 h, followed by the second incubation of 30 min

The drugs efficacy in obese adolescents was also notable, with significant reductions in BMI and higher proportions achieving over 5% and 10% weight loss compared to placebo [38]