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After completing his PhD in 1964, Brown spent the following year, supported by a Wellcome Foundation Travel Award, with Donal Magee, a Scottish born pharmacologist and surgeon based at the University of Washington

52,53 In a phase 2, multi-center trial conducted at 45 centers, orforglipron at doses of 12 mg or greater showed significant reductions in HbA1c and bodyweight compared with placebo or dulaglutide

Another analysis based on 6 publications involving 7221 patients could not confirm that GLP-1RA has an ameliorating effect on AD either [54]

People with certain medical conditions or who are pregnant should avoid it