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Furthermore, the immunoregulatory effects of flavonoids display dose-dependent and cell-specific characteristics, potentially exhibiting bidirectional regulatory effects, thereby complicating their clinical application (11, 12)
and Canadian populations, namely 1.1 mg/day for adult women, 1.4 mg/day during pregnancy, and 1.6 mg/day for lactation 9 , which can be attributed to corresponding regulatory institutions that define criteria for nutritional adequacy in different ways depending on age, sex, and physiological status 10
It suppresses macrophage activation and infiltration, reducing inflammatory mediator release and improving the liver's immune microenvironment
The potential of GHS to complement conventional hypogonadism treatments is garnering attention because, while they don't directly influence testosterone levels, their ability to modulate GH levels might indirectly benefit hypogonadal management
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