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Presented at the LDN AIIC Conference, June 2019 in Portland, OR

For PTH1R 37 and GCGR 38 (whose crystal structures were determined with PGS domain fusion in ICL3 and T4L fusion at ICL2, respectively), agonist binding failed to promote the outward movement of the intracellular half of TM6 as seen in the inactive state, probably due to the fusion

Retatrutide is one of the most advanced multi-agonist peptides currently under investigation