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DNA damaging agents were MMC, cisplatin (Santa Cruz, #sc-200896) and Hydroxyurea (Santa Cruz, #sc-29061) Proteins were visualized using ECL prime chemiluminescence reagent or fluorescence emission

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Currently, in addition to LY3463251, several other GDF-15 agonists are being assessed in early-stage clinical trials, including NNC0247-0829 and JNJ-9090/CIN-109, among others