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Therapeutic potential of Ganoderma lucidum polysaccharide peptide in Doxorubicin-induced nephropathy: modulation of renin-angiotensin system and proteinuria

npj Biofilms Microbiomes 11 , 11 (2025)

This was related to a decreased expression of Ki67 (a marker of cell proliferation) and a downregulation of cyclin A, cyclin D1, and CDK2, which regulate cell cycle progression (31)

AMPK and other signalling pathways, such as the insulin/IGF-1 signalling (IIS), rapamycin-targeting protein (mTOR), nuclear factor-B (NF-B), and deacetylase (Sirtuins) pathways, interact with each other to form a complex network closely related to longevity and ageing [76, 100]