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Siavoshi defines a microdose as the lowest dose of a GLP-1 that lowers food noise without causing any significant weight loss. Food noise, a term used in obesity medicine, refers to chronic unwanted thoughts that make healthful choices (both about how much to eat and what to eat) difficult

Cognitive improvement was observed after 8 weeks of treatment in both females and males, sustained through a 12-week study period, and accompanied by a concurrent reduction in amyloid plaques and neuroinflammation compared to intranasal saline-treated transgenic mice

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