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In these cases, the clinical significance of intervention must be weighed against absolute risk and specific therapeutic goals (54, 118)

Tranexamic acid Extremely stubborn melasma may respond to skin-brightening tranexamic acid, which is available in topical and oral forms

Chem Biol Interact 298:5765 Song M, Xia B, Li J (2006) Effects of topical treatment of sodium butyrate and 5-aminosalicylic acid on expression of trefoil factor 3, interleukin 1beta, and nuclear factor kappaB in trinitrobenzene sulphonic acid induced colitis in rats

He writes: "In light of these findings, clinicians should change how they diagnose and manage MVD