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GSTF8 was the only GST to show specificity for the R-gene response

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The compounds ability to activate the Nrf2-mediated antioxidant response helps mitigate the collateral damage caused by radiation and chemotherapy, particularly in highly vulnerable tissues such as hematopoietic systems and mucosal barriers ( 5.2 Clinical evidence and trial outcomes The translation of SFN from preclinical models to human clinical applications has generated substantial evidence supporting its potential in cancer prevention and management

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