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NICE guidelines (NG28) support their use in specific clinical scenarios, particularly for patients with a BMI 30 kg/m (or 27 kg/m in certain ethnic groups) when HbA1c targets are not met or when weight reduction would provide significant health benefits

168 Indeed, liver biopsies confirm that the prevalence of clinically significant fibrosis in MASLD and MASH patients is only 20.27% and 35.14%, respectively, 169 with lower proportions in patients with normal or lean body weight, 170 suggesting that antifibrotic treatment may not be necessary for a larger proportion of patients

Safety and efficacy of weekly pemvidutide versus placebo for metabolic dysfunction-associated steatohepatitis (IMPACT): 24-week results from a multicentre, randomised, double-blind, phase 2b study

Clinical trials show that semaglutide works a little bit better than liraglutide for most people in promoting weight loss.[ref] What do GLP-1 receptor agonists do