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This communication is important to minimise any adverse side effects or drug interactions that may occur (540)

Innovation/gap filling : Committees consider whether a drug meets significant unmet need, which can bias towards recommendation at the margins (explicit criteria exist in the NICE social value judgments) ( [35] )

We solved cryo-EM structures of OCTN2 (~62.7 kDa) in a substrate-free inward-facing conformation to 3.0 resolution, a carnitine-bound occluded conformation to 2.7 resolution (Fig