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Consequently, clinical communication can shift from binary assertions (effective/ineffective, safe/unsafe) to a framework of probabilities + intervals + acceptance thresholds. For instance, the posterior probability of reaching a clinically meaningful weight-loss threshold can be presented alongside the posterior uncertainty of benefits in hard reproductive endpoints, rather than replacing the decision process with a single P -value

Chwalba A, Dudek A, Otto-Buczkowska E

Evidence to date is primarily derived from preclinical and animal models, with emerging case series data