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It tells the pancreas to release insulin, reduces the production of glucagon, and helps slow down the movement of food through the stomach

Injectable Wegovy demonstrated sustained weight loss of 14% to 17% and provided clear cardiovascular benefit, lowering major adverse cardiovascular events by 20% and all-cause mortality by 19% in patients with established cardiovascular disease

Summary: Feeling cold on retatrutide is most likely caused by rapid weight loss and reduced caloric intake rather than a direct drug effect on thermoregulation

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