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Md Asaduzzaman, Department of Bacteriology, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, 700-8558, Japan, Tel: +81-80 2041 7684, Email: as Activated Pro-Drug Causes Kinase Activation Concurrent with S-glutathionylation of Proteins

The administration of System X c inhibitors can deplete intracellular cysteine, reduce GSH concentration, trigger OS, and increase cell sensitivity to ferroptosis ( Small molecule erastin can directly and selectively target and inhibit the System X c , and irreversibly bind to and inactivate XCT, leading to continuous disorder of cystine uptake, a decrease in cellular antioxidant capacity, and eventually ROS accumulation and ferroptosis (Sato et al., 2018

doi: 10.1182/blood-2015-01-621870 11 MatrePVelezJJacamoRQiYSuXCaiTet al

Plasma and urine pharmacokinetics of free and of short-chain carnitine after administration of carnitine in man