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Long-term use of metformin can lower vitamin B12 levels in some patients

The mortality benefit was most pronounced in patients with Reduced ejection fraction Lower use of other secondary prevention drugs Non-ST-segment elevation myocardial infarction (NSTEMI) There was no significant mortality benefit or reduction in cardiac death, recurrent myocardial infarction, or heart failure readmission with oral beta-blocker therapy for patients with preserved LVEF after acute myocardial infarction treated with percutaneous coronary intervention

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