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Clinical trial results for Setmelanotide in patients with rare genetic variants Between February 2017 and September 2018, single-arm, open-label multicenter phase 3 trials were conducted at 10 different centers, both in the United States and internationally, to evaluate the efficacy and safety of Setmelanotide therapy

GLP-1R agonists show benefits in clinical HF trials but their mode of action in the heart requires further characterization