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These may form a detrimental intergenerational cycle via the maternal metabolic disturbanceplacental functionfetal growth pathway (68, 120122)

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Significantly, a novel rapid arousal intranasal delivery system (RA-IDDS) was developed to ensure targeted delivery of NanoCA to the brain, which provided substantial neuroprotection to alleviate behavioral deficits and enhance the clearance of monomers, oligomers and aggregates of -syn in the midbrain (Liu et al., 2020)

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