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Another study, published in the American Journal of Ophthalmology, used health records from over 37 million people and found that GLP-1 drugs nearly doubled the five-year risk of developing optic nerve damage

Rats receiving brainstem-hypothalamic transection do not have a reduction in food intake in response to peripherally administered GLP-1 which suggests that the brainstem plays a critical role in communicating peripheral satiety signals to higher brain centers (Abbott et al., The hypothalamus has also been implicated as a major center for mediating the pharmacological effects of GLP-1R action on energy metabolism

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[DOI] [PubMed] [Google Scholar] 23.Cochrane Training