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Understanding the bidirectional signaling within the gut-brain-kidney axis opens avenues for novel biomarkers and interventions in CKD management

Patients with a personal or family history of medullary thyroid carcinoma or MEN2 should discuss this with their clinical team before enrolling in any trial involving this drug class

Carriers of the Ala/Ala genotype have been associated with reduced psychological well-being, decreased responsiveness to levothyroxine therapy, and increased risk of hypothyroid symptoms despite normal serum TSH and T4 levels [82]

All these benefits are helpful for protecting cells and maintaining overall cellular balance