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Both cross the bloodbrain barrier and have been shown to lower nighttime cortisol by dampening the hypothalamicpituitaryadrenal (HPA) axis, which in turn reduces stressinduced awakenings

Small pilot studies have begun to explore this application more systematically

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[1] [5] Patients with a personal or family history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2) should discuss these conditions with their healthcare provider, as GLP-1 receptor agonists have been associated with thyroid C-cell tumours in animal studies