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Ethics, reproducibility and methodological pitfalls Frequent pitfalls in cognitive peptide research No vehicle control in some old Russian studies: mandatory in any modern publication Non-randomisation : assigning animals to groups by order of arrival introduces systematic bias (weight, oestral cycle, cage stress) Non-blinded experimenter : behavioural tests are highly sensitive to expectations

Delivery system innovations, particularly nano-encapsulation and lyophilized (freeze-dried) powders for reconstitution, are improving peptide stability and bioavailability, boosting product performance

Higher is not always better: 9 mg often delivers a better efficacy-to-tolerability ratio than 12 mg

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