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Keywords: Alport syndrome (AS), Chronic kidney disease (CKD), Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), Nephroprotection, Collagen IV, Genetic kidney disease Introduction For decades, patients with chronic kidney disease (CKD) had no pharmacological options to slow disease progression besides renin-angiotensin system (RASi) blockade, which were introduced into clinical practice in the early 1980s

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