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Acetaminophen toxicity: The most well-established clinical application of glutathione repletion is the treatment of acetaminophen (paracetamol) overdose

Usually a few sessions, a few weeks apart are needed

Regular infusions can act as a preventive measure , especially during Michigans cold winter months

As both H 2 O 2 and BCNU exposure led to excessive cellular GSSG accumulation, their impact on intracellular protein-GSSG adduct formation (protein S -glutathionylation) was subsequently examined in HepG2 cells by western blot analysis using a monoclonal GSSG antibody that specifically binds to GSSG-modified proteins