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(2010) using a novel phosphoselective antibody for pY166 in the Asp-Arg-Tyr motif of MOR, showed increased phosphorylation of this site only when the receptor was coactivated both by DAMGO and stress (H 2 O 2 ) or the tyrosine kinase agonist epithelial growth factor

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To further characterize these interactions, we constructed a molecular interaction network (Figure 7C) revealed three functionally interconnected modules: (Young et al., 1990) an oxidative stress module linking Gpx3 with glutathione metabolites, and ( Consistent with multi-omics findings, KEGG pathway analysis identified glutathione metabolism as the most significantly perturbed shared pathway (Figure 8A), exhibiting coordinated changes between upregulated antioxidant enzymes such as Gpx3 and Mgst1 alongside depleted glutathione derivatives, supporting redox imbalance as a key pathogenic feature

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