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A related possibility is that some hindbrain neurons express both the estrogen receptor and GLP1R, and that activation of the former (by estrogen) amplifies signal transduction of the latter (by a GLP1R agonist)

Acetyl-L-carnitine supplementation to old rats partially reverts the age-related mitochondrial decay of soleus muscle by activating peroxisome proliferator-activated receptor gamma coactivator-1alpha-dependent mitochondrial biogenesis