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More recently, encouraging clinical results from a triple-hormone-receptor agonist, Retatrutide, and several GLP-1R/GCGR dual agonists, suggest that GCGR could be a promising co-stimulating target for type 2 diabetes and obesity.

The newer generation tells a more compelling story

Diabetologia 52 , 20462055 (2009)

Some practical dietary strategies include: Smaller portion sizes : Eating until comfortably satisfied rather than full reduces the risk of nausea and discomfort Bland, easily digestible foods : During dose escalation, focus on lean proteins, whole grains, and cooked vegetables Adequate hydration : Sipping water throughout the day, particularly if experiencing nausea or constipation Avoiding trigger foods : Identifying and temporarily limiting foods that worsen individual symptoms Persistent vomiting or diarrhea can lead to dehydration and potentially acute kidney injury