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Surprisingly, the CX-DM1-containing ADCs possessed higher in vivo activity and a 50-fold higher preclinical therapeutic index [maximum tolerated dose/minimum effective dose (MTD/MED) ratio] than SMCC-DM1-containing ADCs in both the EGFR and EpCAM xenograft mouse models

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Under pathological conditions, cholesterol homeostasis is disrupted, and the efferocytosis function of macrophages is similarly affected