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Even if the compound enters the target tissue/organ, it may not reach the active sites of oxidative damage (e.g., mitochondria)

Finerenone with empagliflozin in chronic kidney disease and type 2 diabetes N Engl J Med 2025

A molecule present in the skin attracts and retains moisture, nourishes the body and wards off dull and dry skin issues

The delayed gastric emptying induced by semaglutide can increase gastric pressure and volume, potentially promoting reflux of gastric contents into the esophagus