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Endogenous sources of ROS include several cellular enzymes such as nicotinamide adenine dinucleotide phosphate (NADPH) oxidase (Nox), xanthine oxidase (XO), mitochondrial oxidases, cyclooxygenase, myeloperoxidase, amino acid oxidase, lipoxygenase, and peroxisomes
As sDPP4 is an adipokine upregulated in obesity and T2DM that triggers IR and metabolic complications (4, 5), it might be speculated that the beneficial effects of DPP4 inhibitors would be higher in those early phases of the metabolic disorders previous to the development of established cardiovascular disease
Shadid S, Jensen MD
Oral melatonin supplementation during in vitro fertilization treatment: a systematic PRISMA review and meta-analysis of randomized controlled trials
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