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10.3389/fonc.2022.1107505 154 XieY.HouW.SongX.YuY.HuangJ.SunX.et al (2016)

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In general, use caution when selecting a dosage for an elderly patient, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function and of concomitant disease or other drug therapy

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