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Why this matters for drug discovery Editor's note: Updated July 27, 2026 with the published evoke and evoke+ biomarker data from The Lancet, including neurofilament light and GFAP results that point in conflicting directions

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To view digital features for this article go to Introduction Glucagon-like peptide-1 receptor agonists (GLP-1 RAs), a class of incretin-based therapies for the treatment of type 2 diabetes (T2D), have been shown to be highly effective for both glycaemic control and weight loss, and are associated with a low risk of hypoglycaemia [1]

The constant background noise of food thoughts quieted down significantly