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Patient management should include discontinuation of the offending medications, supportive management, and aggressive treatment of the associated risk factors, for example, sepsis

Flow-Dependent Elimination In contrast to capacity-limited drug elimination, some drugs are cleared very readily by the organ of elimination, so that at any clinically realistic concentration of the drug, most of the drug in the blood perfusing the organ is eliminated on the first pass of the drug through it

"Deficient synthesis of glutathione underlies oxidative stress in aging and can be corrected by dietary cysteine and glycine supplementation"

L-Glutathione can be depleted under heavy bouts of free radical stress or even simply due to aging, as L-glutathione levels naturally decrease over time