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These chemical scaffolds frequently yield screening hits due to nonspecific interfering mechanisms such as redox cycling that can generate reactive oxygen species or covalent adducts and metal chelation that can disrupt metalloenzyme function, leading to false-positive results across diverse assay formats (Hermann et al., 2012

Anyway, today, the consensus is that the usual doses of Tylenol cause significant liver damage only rarely, or not at all in people with normal livers

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