however, several other medications are beneficial 46 (Table 5 27,28,4752 )
In addition, astrocytes, which normally support neurons, become dysfunctional through a process called astrogliosis, which worsens glutamate imbalance and reduces neuronal support (Taylor et al., 2016), and genetic mutationssuch as SOD1 (causing harmful protein accumulation), FUS (interfering with RNA handling), and TBK1 or OPTN (which impair the cell's waste disposal system known as autophagy
or inflammation associated with the gradual degeneration of the cartilage-bearing surfaces (arthritis)
nevertheless, animal models have indicated reproductive toxicity and development retardation at excessively high doses (Gota et al., 2010)