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Through 10 fold cross validation, over 99% prediction accuracy was achieved using both support vector machine (SVM) and random forest based classification methods in a dataset of 1134 sequences for NS5B and 947 sequences for E1

10 Importantly, this suppression is not observed during daytime fasting when gut hormone secretion is reduced, 14 highlighting direct effects of peptide hormones on bone turnover in response to nutritional status

This dual mechanism addresses metabolic dysregulation at multiple points

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