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Funding for this research was provided by gifts from RAND supporters and income from the operation of RAND Survey Panels

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The results indicated that CA, with its strong UV absorption, ultra-wide mass detection range (close to 200,000 Da), m-scale size matrix crystals, uniform matrix deposition, and high ionization efficiency, has the potential to become a standard organic acid matrix for enhanced tissue imaging of HMW proteins in animal and plant tissues by MALDI-MSI

Variants in genes encoding glutathione synthesis, detoxification enzyme activity, and Phase II function can inform whether supplemental glutathione or milk thistle addresses a meaningful metabolic bottleneck