Funding This work was supported by grants from The Guangdong Basic and Applied Basic Research Foundation (grant numbers: 2022A1515220187 and 2019A1515111018), National Natural Science Foundation of China (grant number: 82102689), the Excellent Young Researchers Program of the Fifth Affiliated Hospital of Sun Yat-sen University (2023080017 and WYYXQN-2021016), Fundamental Research Funds for the Central Universities of Sun Yat-sen University (grant number: 22qntd3502), the Project of Guiyang Health and Family Planning Commission (grant number: 2018-016), and Yunnan Province Applied Basic Research Program Kunming Medical University Joint Project (202401AY070001-120)
Recent investigations have reported that PIK3CA mutations modulate SIRT4 expression through negative regulation of the epigenetic factor EP300, ultimately influencing GPT1 and altering glutamine metabolism in cancer [99]
Having too much of any neurotransmitter is just as bad as not having enough and can lead to unpleasant side effects like headaches, stomach aches, tremors, or serious complications like serotonin syndrome.40 Serotonin This neurotransmitter is responsible for our mood, sleep, and digestion, and it stabilizes other neurotransmitters
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