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Stay hydrated : Dehydration can worsen side effects like headache or fatigue

After taking the daily pill for about 15 months, heres what participants experienced: Average weight loss of 13.6% across all participants, even those who werent perfectly consistent 16.6% average loss when the medication was taken consistently More than 3 out of 4 participants lost at least 5% of their body weight About 1 in 3 hit the 20% mark or higher But the benefits went beyond what the scale showed

doi: 10.1210/er.2002-0029 81 VolanteM.AlliaE.FulcheriE.CassoniP.GhigoE.MuccioliG.et al

(30921021, 33176370, 37259844) In contrast, valproic acid and phenobarbital both work via different mechanisms (largely by modulating the GABA system), which should synergize better with lacosamide