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or a lettuce leaf instead of bread

Fighting extreme hunger with severe restriction will backfire, leading to binge episodes and potentially larger weight regain than a moderate approach

But optimizing your protocol over time is what produces exceptional results

injections of 50 mol kg 1 memantine (n = 6 mice and n = 3 cages), 125 mol kg 1 memantine (n = 6 mice and n = 3 cages) or vehicle (isotonic saline, n = 6 mice and n = 3 cages) over 7 days