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However, although commonly reported by patients, these symptoms are mostly mild, are rarely a reason for discontinuation of therapy, and seem to decrease over time with ongoing treatment.7,25e27 Although gastrointestinal side-effects occurred commonly in the large cardiovascular outcome trials, most were reported in the first weeks after initiation and they only led to discontinuation of treatment in 1e3% of cases.10,11 On the ICU, GLP-1 was also found to decrease gastric motility, although its effect was minimal when gastric emptying was already delayed.28 In patients with diabetes mellitus, gastroparesis is a known complication that requires attention and appropriate action by anaesthesiologists

(ii) Sequential model I: Psychotherapy or behavioral stabilization is initiated first, followed by GLP-1 RA treatment

Prolonged use without exercise or strength training can also strip away muscle along with fat

A 2024 study reviewed data from the national databases to understand the effects of diet and exercise on constipation