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Some discontinue the sulfonylurea entirely once semaglutide reaches a therapeutic dose, since both target post-meal glucose and the GLP-1 mechanism is more physiologic

Large, long-term outcome studies show that GLP-1 therapies improve outcomes and reduce the incidence of diseases closely linked to inflammation, including osteoarthritis, cardiovascular disease, fatty liver disease, chronic kidney disease, Alzheimers, and autoimmune conditions

As the incidence of these complications is low, we can still prescribe as is clinically indicated

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